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SIRT1 targets over 100 different proteins involved in metabolism, stress responses, and longevity pathways, including the tumor suppressor p53, the transcriptional coactivator PGC-1, and the DNA repair protein Ku70. Through deacetylation of PGC-1, SIRT1 promotes mitochondrial biogenesis and oxidative metabolism, while deacetylation of p53 reduces apoptotic responses to mild stress, promoting cellular survival and longevity

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18 The gut microbiota is crucial for the maintenance of intestinal barrier integrity, regulation of gut homeostasis, and stimulation of the host immune response

Protection of tissue structures under stress

Lysozymes Lysozymes are glycoside hydrolases that cleave -(1,4)-glycosidic bonds of bacterial cell walls [44]